Social innovators and social entrepreneurs can play an important role in finding creative and unconventional solutions to current transformative challenges such as migration, the transition to a carbon neutral society, or digitisation. But to turn good ideas into practice they need help – in terms of qualification, funding and access to markets and cooperation partners. Regional public authorities, business support organisations and sectoral agencies in the Baltic Sea Region are already very effectively providing such support to mainstream innovators and entrepreneurs, but they have yet to realise the benefits of adapting their offers to the needs of social enterprises. The RESIST project supports these institutions in creating better and more supportive regional ecosystems for social innovation (SI) and social entrepreneurship (SE) and in making existing innovation support more accessible for social entrepreneurs. The project partners explore the concept of “clusters of social and ecological innovation” (CSEI) as a model for fostering cross-sectoral collaboration, and they develop and test a programme to improve the capacity of innovation support actors to foster social innovation. In the long run, the objective is to raise the number of CSEIs in the BSR and to facilitate cooperation between them. Throughout the process, the involved regions will also collect ideas and recommendations for improving the integration of social innovation in their regional innovation strategies.